1. de Grey,AD, Ending Aging, St. Martin's Press, 2007 2. de Grey AD, Protagonistic pleiotropy: Why cancer may be the only pathogenic effect of accumulating nuclear mutations and epimutations in aging. Mech Ageing Dev. 2007 Jul-Aug;128(7-8):456-9. 3. Lindahl T, Instability and decay of the primary structure of DNA. Nature. 1993 Apr 22;362(6422):709-15. 4. Tice,RR and Setlow,RB "DNA Repair and Replication in Aging Organisms and Cells" in Handbook of the Biology of Aging (2nd Edition), Finch,CE and Schneider,EL (Editors), Van Nostrand Reinhold Company 1985, pp.173-224. 5. Hanawalt,PC "On the Role of DNA Damage and Repair Processing in Aging: Evidence For and Against" in Modern Biological Theories of Aging, Warner,HR, et.al. (Editors), Raven Press 1987, pp.183-198. 6. Mullaart E, Lohman PH, Berends F, Vijg J, DNA damage metabolism and aging. Mutat Res. 1990 Sep-Nov;237(5-6):189-210.7 7. Mullaart E, Roza L, Lohman PH, Vijg J, The removal of UV-induced pyrimidine dimers from DNA of rat skin cells in vitro and in vivo in relation to aging. Mech Ageing Dev. 1989 Mar;47(3):253-64. 8. Gorbunova V, Seluanov A, Mao Z, Hine C, Changes in DNA repair during aging. Nucleic Acids Res. 2007;35(22):7466-74. 9. DePinho RA, The age of cancer. Nature. 2000 Nov 9;408(6809):248-54. 10. Singh NP, Ogburn CE, Wolf NS, van Belle G, Martin GM. DNA double-strand breaks in mouse kidney cells with age. Biogerontology. 2001;2(4):261-70. 11. Bailey KJ, Maslov AY, Pruitt SC, Accumulation of mutations and somatic selection in aging neural stem/progenitor cells. Aging Cell. 2004 Dec;3(6):391-7. 12. Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL, Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature. 2007 Jun 7;447(7145):725-9. 13. Richter C, Park JW, Ames BN, Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6465-7. 14. Hamilton ML, Van Remmen H, Drake JA, Yang H, Guo ZM, Kewitt K, Walter CA, Richardson A, Does oxidative damage to DNA increase with age? Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10469-74. 15. Haripriya D, Sangeetha P, Kanchana A, Balu M, Panneerselvam C, Modulation of age-associated oxidative DNA damage in rat brain cerebral cortex, striatum and hippocampus by L-carnitine. Exp Gerontol. 2005 Mar;40(3):129-35. 16. Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA, Gene regulation and DNA damage in the ageing human brain. Nature. 2004 Jun 24;429(6994):883-91. 17. Busuttil RA, Garcia AM, Reddick RL, Dollé ME, Calder RB, Nelson JF, Vijg J, Intra-organ variation in age-related mutation accumulation in the mouse. PLoS ONE. 2007 Sep 12;2(9):e876. 18. Stuart GR, Glickman BW, Through a glass, darkly: reflections of mutation from lacI transgenic mice. Genetics. 2000 Jul;155(3):1359-67. 19. Mandavilli BS, Rao KS, Neurons in the cerebral cortex are most susceptible to DNA-damage in aging rat brain. Biochem Mol Biol Int. 1996 Oct;40(3):507-14. 20. Bennett-Baker PE, Wilkowski J, Burke DT, Age-associated activation of epigenetically repressed genes in the mouse. Genetics. 2003 Dec;165(4):2055-62. 21. López-Diazguerrero NE, Luna-López A, Gutiérrez-Ruiz MC, Zentella A, Königsberg M, Susceptibility of DNA to oxidative stressors in young and aging mice. Life Sci. 2005 Oct 14;77(22):2840-54. 22. Wilson VL, Smith RA, Ma S, Cutler RG. Genomic 5-methyldeoxycytidine decreases with age. J Biol Chem. 1987 Jul 25;262(21):9948-51. 23. Bahar R, Hartmann CH, Rodriguez KA, Denny AD, Busuttil RA, Dollé ME, Calder RB, Chisholm GB, Pollock BH, Klein CA, Vijg J, Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature. 2006 Jun 22;441(7096):1011-4. 24. Sawada N, Ishikawa T, Reduction of potential for replicative but not unscheduled DNA synthesis in hepatocytes isolated from aged as compared to young rats. Cancer Res. 1988 Mar 15;48(6):1618-22. 25. Somel M, Khaitovich P, Bahn S, Pääbo S, Lachmann M, Gene expression becomes heterogeneous with age. Curr Biol. 2006 May 23;16(10):R359-60. 26. Grove GL, Kligman AM, Age-associated changes in human epidermal cell renewal. J Gerontol. 1983 Mar;38(2):137-42. 27. Siomek A, Gackowski D, Rozalski R, Dziaman T, Szpila A, Guz J, Olinski R, Higher leukocyte 8-oxo-7,8-dihydro-2'-deoxyguanosine and lower plasma ascorbate in aging humans? Antioxid Redox Signal. 2007 Jan;9(1):143-50. 28. ***************************************************** 29. Friedburg,EC, et.al. (Editors), DNA Repair and Mutagenesis (2nd Edition), ASM Press, 2006. 30. Mazurek A, Berardini M, Fishel R, Activation of human MutS homologs by 8-oxo-guanine DNA damage. J Biol Chem. 2002 Mar 8;277(10):8260-6. 31. Li GM, Mechanisms and functions of DNA mismatch repair. Cell Res. 2008 Jan;18(1):85-98. 32. Hasty P, Campisi J, Hoeijmakers J, van Steeg H, Vijg J, Aging and genome maintenance: lessons from the mouse? Science. 2003 Feb 28;299(5611):1355-9. 33. Ljungman M, Lane DP. Transcription - guarding the genome by sensing DNA damage. Nat Rev Cancer. 2004 Sep;4(9):727-37. 34. Christiansen M, Stevnsner T, Bohr VA, Clark BF, Rattan SI, Gene-specific DNA repair of pyrimidine dimers does not decline during cellular aging in vitro. Exp Cell Res. 2000 Apr 10;256(1):308-14. 35. Mori M, Kobayashi H, Sugiyama C, Katsumura Y, Furihata C, Effect of aging on unscheduled DNA synthesis induction by UV-B irradiation in hairless mouse epidermis. J Toxicol Sci. 2000 Aug;25(3):181-8. 36. Merkle TJ, O'Brien K, Brooks PJ, Tarone RE, Robbins JH, DNA repair in human fibroblasts, as reflected by host-cell reactivation of a transfected UV-irradiated luciferase gene, is not related to donor age. Mutat Res. 2004 Oct 4;554(1-2):9-17. 37. Hazane F, Sauvaigo S, Douki T, Favier A, Beani JC, Age-dependent DNA repair and cell cycle distribution of human skin fibroblasts in response to UVA irradiation. J Photochem Photobiol B. 2006 Mar 1;82(3):214-23. 38. Takahashi Y, Moriwaki S, Sugiyama Y, Endo Y, Yamazaki K, Mori T, Takigawa M, Inoue S, Decreased gene expression responsible for post-ultraviolet DNA repair synthesis in aging: a possible mechanism of age-related reduction in DNA repair capacity. J Invest Dermatol. 2005 Feb;124(2):435-42. 39. Guo Z, Heydari A, Richardson A, Nucleotide excision repair of actively transcribed versus nontranscribed DNA in rat hepatocytes: effect of age and dietary restriction. Exp Cell Res. 1998 Nov 25;245(1):228-38. 40. Yamada M, Udono MU, Hori M, Hirose R, Sato S, Mori T, Nikaido O, Aged human skin removes UVB-induced pyrimidine dimers from the epidermis more slowly than younger adult skin in vivo. Arch Dermatol Res. 2006 Jan;297(7):294-302. 41. Goukassian D, Gad F, Yaar M, Eller MS, Nehal US, Gilchrest BA, Mechanisms and implications of the age-associated decrease in DNA repair capacity. FASEB J. 2000 Jul;14(10):1325-34. 42. Moriwaki S, Takahashi Y, Photoaging and DNA repair. J Dermatol Sci. 2008 Jun;50(3):169-76. 43. Goukassian DA, Bagheri S, el-Keeb L, Eller MS, Gilchrest BA, DNA oligonucleotide treatment corrects the age-associated decline in DNA repair capacity. FASEB J. 2002 May;16(7):754-6. 44. Atamna H, Cheung I, Ames BN, A method for detecting abasic sites in living cells: age-dependent changes in base excision repair. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):686-91. 45. Chen SK, Hsieh WA, Tsai MH, Chen CC, Hong AI, Wei YH, Chang WP, Age-associated decrease of oxidative repair enzymes, human 8-oxoguanine DNA glycosylases (hOgg1), in human aging. J Radiat Res (Tokyo). 2003 Mar;44(1):31-5. 46. Intano GW, McMahan CA, McCarrey JR, Walter RB, McKenna AE, Matsumoto Y, MacInnes MA, Chen DJ, Walter CA. Base excision repair is limited by different proteins in male germ cell nuclear extracts prepared from young and old mice. Mol Cell Biol. 2002 Apr;22(7):2410-8. 47. Imam SZ, Karahalil B, Hogue BA, Souza-Pinto NC, Bohr VA, Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner. Neurobiol Aging. 2006 Aug;27(8):1129-36. 48. Hashimoto K, Takasaki W, Sato I, Tsuda S, DNA damage measured by comet assay and 8-OH-dG formation related to blood chemical analyses in aged rats. J Toxicol Sci. 2007 Aug;32(3):249-59. 49. Cabelof DC, Raffoul JJ, Yanamadala S, Ganir C, Guo Z, Heydari AR, Attenuation of DNA polymerase beta-dependent base excision repair and increased DMS-induced mutagenicity in aged mice. Mutat Res. 2002 Mar 20;500(1-2):135-45. 50. Cabelof DC, Raffoul JJ, Ge Y, Van Remmen H, Matherly LH, Heydari AR, Age-related loss of the DNA repair response following exposure to oxidative stress. J Gerontol A Biol Sci Med Sci. 2006 May;61(5):427-34. 51. Rao KS, Annapurna VV, Raji NS, DNA polymerase-beta may be the main player for defective DNA repair in aging rat neurons. Ann N Y Acad Sci. 2001 Apr;928:113-20. 52. Krishna TH, Mahipal S, Sudhakar A, Sugimoto H, Kalluri R, Rao KS, Reduced DNA gap repair in aging rat neuronal extracts and its restoration by DNA polymerase beta and DNA-ligase. J Neurochem. 2005 Feb;92(4):818-23. 53. Kaneko T, Tahara S, Tanno M, Taguchi T, Age-related changes in the induction of DNA polymerases in rat liver by gamma-ray irradiation. Mech Ageing Dev. 2002 Sep;123(11):1521-8. 54. Rao KS, DNA repair in aging rat neurons. Neuroscience. 2007 Apr 14;145(4):1330-40. 55. Intano GW, Cho EJ, McMahan CA, Walter CA, Age-related base excision repair activity in mouse brain and liver nuclear extracts. J Gerontol A Biol Sci Med Sci. 2003 Mar;58(3):205-11. 56. Sharma S, Age-related nonhomologous end joining activity in rat neurons. Brain Res Bull. 2007 Jun 15;73(1-3):48-54. 57. Vyjayanti VN, Rao KS, DNA double strand break repair in brain: reduced NHEJ activity in aging rat neurons. Neurosci Lett. 2006 Jan 23;393(1):18-22. 58. Ren K, de Ortiz SP, Non-homologous DNA end joining in the mature rat brain. J Neurochem. 2002 Mar;80(6):949-59. 59. Schmitz C, Axmacher B, Zunker U, Korr H, Age-related changes of DNA repair and mitochondrial DNA synthesis in the mouse brain. Acta Neuropathol. 1999 Jan;97(1):71-81. 60. Ju YJ, Lee KH, Park JE, Yi YS, Yun MY, Ham YH, Kim TJ, Choi HM, Han GJ, Lee JH, Lee J, Han JS, Lee KM, Park GH, Decreased expression of DNA repair proteins Ku70 and Mre11 is associated with aging and may contribute to the cellular senescence. Exp Mol Med. 2006 Dec 31;38(6):686-93. 61. Doria G, Barattini P, Scarpaci S, Puel A, Guidi L, Frasca D, Role of immune responsiveness and DNA repair capacity genes in ageing. Ageing Res Rev. 2004 Apr;3(2):143-51. 62. Prall WC, Czibere A, Jäger M, Spentzos D, Libermann TA, Gattermann N, Haas R, Aivado M, Age-related transcription levels of KU70, MGST1 and BIK in CD34+ hematopoietic stem and progenitor cells. Mech Ageing Dev. 2007 Sep;128(9):503-10. 63. Hart RW, Setlow RB, Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species. Proc Natl Acad Sci U S A. 1974 Jun;71(6):2169-73. 64. Cortopassi GA, Wang E, There is substantial agreement among interspecies estimates of DNA repair activity. Mech Ageing Dev. 1996 Nov 13;91(3):211-8. 65. Beneke S, Bürkle A, Poly(ADP-ribosyl)ation in mammalian ageing. Nucleic Acids Res. 2007;35(22):7456-65. 66. Grube K, Bürkle A, Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11759-63. 67. Bürkle A, Beneke S, Brabeck C, Leake A, Meyer R, Muiras ML, Pfeiffer R, Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity. Exp Gerontol. 2002 Oct-Nov;37(10-11):1203-5. 68. Simm A, Nass N, Bartling B, Hofmann B, Silber RE, Navarrete Santos A, Potential biomarkers of ageing. Biol Chem. 2008 Mar;389(3):257-65. 69. Nilsson PM, Early vascular aging (EVA): consequences and prevention. Vasc Health Risk Manag. 2008;4(3):547-52. 70. Cerami C, Founds H, Nicholl I, Mitsuhashi T, Giordano D, Vanpatten S, Lee A, Al-Abed Y, Vlassara H, Bucala R, Cerami A. Tobacco smoke is a source of toxic reactive glycation products. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13915-20. 71. Koschinsky T, He CJ, Mitsuhashi T, Bucala R, Liu C, Buenting C, Heitmann K, Vlassara H, Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6474-9. 72. Miller RA, 'Accelerated aging': a primrose path to insight? Aging Cell. 2004 Apr;3(2):47-51. 73. El-Domyati M, Attia S, Saleh F, Brown D, Birk DE, Gasparro F, Ahmad H, Uitto J, Intrinsic aging vs. photoaging: a comparative histopathological, immunohistochemical, and ultrastructural study of skin. Exp Dermatol. 2002 Oct;11(5):398-405. 74. Yaar M, Gilchrest BA, Photoageing: mechanism, prevention and therapy. Br J Dermatol. 2007 Nov;157(5):874-87. 75. Quan T, He T, Kang S, Voorhees JJ, Fisher GJ, Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-beta type II receptor/Smad signaling. Am J Pathol. 2004 Sep;165(3):741-51. 76. Kozmin S, Slezak G, Reynaud-Angelin A, Elie C, de Rycke Y, Boiteux S, Sage E, UVA radiation is highly mutagenic in cells that are unable to repair 7,8-dihydro-8-oxoguanine in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13538-43. 77. Debacq-Chainiaux F, Borlon C, Pascal T, Royer V, Eliaers F, Ninane N, Carrard G, Friguet B, de Longueville F, Boffe S, Remacle J, Toussaint O, Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-beta1 signaling pathway. J Cell Sci. 2005 Feb 15;118(Pt 4):743-58. 78. Niedernhofer LJ, Tissue-specific accelerated aging in nucleotide excision repair deficiency. Mech Ageing Dev. 2008 Jul-Aug;129(7-8):408-15. 79. Goto M, Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing. Mech Ageing Dev. 1997 Dec;98(3):239-54. 80. Prince PR, Emond MJ, Monnat RJ Jr, Loss of Werner syndrome protein function promotes aberrant mitotic recombination. Genes Dev. 2001 Apr 15;15(8):933-8. 81. Saintigny Y, Makienko K, Swanson C, Emond MJ, Monnat RJ Jr, Homologous recombination resolution defect in werner syndrome. Mol Cell Biol. 2002 Oct;22(20):6971-8. 82. Goto M, Miller RW, Ishikawa Y, Sugano H, Excess of rare cancers in Werner syndrome (adult progeria). Cancer Epidemiol Biomarkers Prev. 1996 Apr;5(4):239-46. 83. Faragher RG, Kill IR, Hunter JA, Pope FM, Tannock C, Shall S, The gene responsible for Werner syndrome may be a cell division "counting" gene. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):12030-4. 84. Ariyoshi K, Suzuki K, Goto M, Watanabe M, Kodama S, Increased chromosome instability and accumulation of DNA double-strand breaks in Werner syndrome cells. J Radiat Res (Tokyo). 2007 May;48(3):219-31. 85. Kumar S, Vinci JM, Millis AJ, Baglioni C, Expression of interleukin-1 alpha and beta in early passage fibroblasts from aging individuals. Exp Gerontol. 1993 Nov-Dec;28(6):505-13. 86. Davis T, Kipling D, Werner Syndrome as an example of inflamm-aging: possible therapeutic opportunities for a progeroid syndrome? Rejuvenation Res. 2006 Fall;9(3):402-7. 87. Sasaki M, Ikeda H, Sato Y, Nakanuma Y, Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress and activation of ATM pathway: a culture study. Free Radic Res. 2008 Jul;42(7):625-32. 88. Kyng KJ, May A, Kølvraa S, Bohr VA, Gene expression profiling in Werner syndrome closely resembles that of normal aging. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12259-64. 89. Kipling D, Davis T, Ostler EL, Faragher RG, What can progeroid syndromes tell us about human aging? Science. 2004 Sep 3;305(5689):1426-31. 90. Pichierri P, Franchitto A, Mosesso P, Palitti F, Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle. Mol Biol Cell. 2001 Aug;12(8):2412-21. 91. Hennekam RC, Hutchinson-Gilford progeria syndrome: review of the phenotype. Am J Med Genet A. 2006 Dec 1;140(23):2603-24. 92. Liu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadiñanos J, López-Otín C, Tse HF, Hutchison C, Chen J, Cao Y, Cheah KS, Tryggvason K, Zhou Z, Genomic instability in laminopathy-based premature aging. Nat Med. 2005 Jul;11(7):780-5. 93. Manju K, Muralikrishna B, Parnaik VK, Expression of disease-causing lamin A mutants impairs the formation of DNA repair foci. J Cell Sci. 2006 Jul 1;119(Pt 13):2704-14. 94. Paulsen RD, Cimprich KA, The ATR pathway: fine-tuning the fork. DNA Repair (Amst). 2007 Jul 1;6(7):953-66. 95. Scaffidi P, Misteli T, Lamin A-dependent nuclear defects in human aging. Science. 2006 May 19;312(5776):1059-63. 96. Bridger JM, Kill IR, Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis. Exp Gerontol. 2004 May;39(5):717-24. 97. Botta E, Nardo T, Lehmann AR, Egly JM, Pedrini AM, Stefanini M, Reduced level of the repair/transcription factor TFIIH in trichothiodystrophy. Hum Mol Genet. 2002 Nov 1;11(23):2919-28. 98. de Boer J, Andressoo JO, de Wit J, Huijmans J, Beems RB, van Steeg H, Weeda G, van der Horst GT, van Leeuwen W, Themmen AP, Meradji M, Hoeijmakers JH, Premature aging in mice deficient in DNA repair and transcription. Science. 2002 May 17;296(5571):1276-9. 99. Niedernhofer LJ, Odijk H, Budzowska M, van Drunen E, Maas A, Theil AF, de Wit J, Jaspers NG, Beverloo HB, Hoeijmakers JH, Kanaar R, The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks. Mol Cell Biol. 2004 Jul;24(13):5776-87. 100. McHugh PJ, Spanswick VJ, Hartley JA, Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance. Lancet Oncol. 2001 Aug;2(8):483-90. 101. Niedernhofer LJ, Garinis GA, Raams A, Lalai AS, Robinson AR, Appeldoorn E, Odijk H, Oostendorp R, Ahmad A, van Leeuwen W, Theil AF, Vermeulen W, van der Horst GT, Meinecke P, Kleijer WJ, Vijg J, Jaspers NG, Hoeijmakers JH, A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature. 2006 Dec 21;444(7122):1038-43. 102. Symphorien S, Woodruff RC, Effect of DNA repair on aging of transgenic Drosophila melanogaster: I. mei-41 locus.J Gerontol A Biol Sci Med Sci. 2003 Sep;58(9):B782-7. 103. Sedelnikova OA, Horikawa I, Zimonjic DB, Popescu NC, Bonner WM, Barrett JC, Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat Cell Biol. 2004 Feb;6(2):168-70. 104. von Zglinicki T, Saretzki G, Ladhoff J, d'Adda di Fagagna F, Jackson SP, Human cell senescence as a DNA damage response. Mech Ageing Dev. 2005 Jan;126(1):111-7. 105. d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T, Saretzki G, Carter NP, Jackson SP. A DNA damage checkpoint response in telomere-initiated senescence. Nature. 2003 Nov 13;426(6963):194-8. 106. Herbig U, Ferreira M, Condel L, Carey D, Sedivy JM, Cellular senescence in aging primates. Science. 2006 Mar 3;311(5765):1257. 107. Campisi J, d'Adda di Fagagna F, Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol. 2007 Sep;8(9):729-40. 108. Coppé JP, Kauser K, Campisi J, Beauséjour CM, Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J Biol Chem. 2006 Oct 6;281(40):29568-74. 109. Krtolica A, Parrinello S, Lockett S, Desprez PY, Campisi J, Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12072-7. 110. Aylon Y, Oren M, Living with p53, dying of p53. Cell. 2007 Aug 24;130(4):597-600. 111: Matheu A, Maraver A, Serrano M, The Arf/p53 pathway in cancer and aging. Cancer Res. 2008 Aug 1;68(15):6031-4. 112. Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, Lu X, Soron G, Cooper B, Brayton C, Hee Park S, Thompson T, Karsenty G, Bradley A, Donehower LA, p53 mutant mice that display early ageing-associated phenotypes. Nature. 2002 Jan 3;415(6867):45-53. 113. Maier B, Gluba W, Bernier B, Turner T, Mohammad K, Guise T, Sutherland A, Thorner M, Scrable H, Modulation of mammalian life span by the short isoform of p53. Genes Dev. 2004 Feb 1;18(3):306-19. 114. Dumble M, Moore L, Chambers SM, Geiger H, Van Zant G, Goodell MA, Donehower LA, The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging. Blood. 2007 Feb 15;109(4):1736-42. 115. Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lanfrancone L, Pelicci PG, The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature. 1999 Nov 18;402(6759):309-13. 116. Gil J, Peters G, Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat Rev Mol Cell Biol. 2006 Sep;7(9):667-77. 117. Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L, Sharpless NE, Ink4a/Arf expression is a biomarker of aging. J Clin Invest. 2004 Nov;114(9):1299-307. 118. Ressler S, Bartkova J, Niederegger H, Bartek J, Scharffetter-Kochanek K, Jansen-Dürr P, Wlaschek M, p16INK4A is a robust in vivo biomarker of cellular aging in human skin. Aging Cell. 2006 Oct;5(5):379-89. 119. Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, Bonner-Weir S, Sharpless NE, p16INK4a induces an age-dependent decline in islet regenerative potential. Nature. 2006 Sep 28;443(7110):453-7. 120. Molofsky AV, Slutsky SG, Joseph NM, He S, Pardal R, Krishnamurthy J, Sharpless NE, Morrison SJ, Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature. 2006 Sep 28;443(7110):448-52. 121. Matheu A, Maraver A, Klatt P, Flores I, Garcia-Cao I, Borras C, Flores JM, Viña J, Blasco MA, Serrano M, Delayed ageing through damage protection by the Arf/p53 pathway. Nature. 2007 Jul 19;448(7151):375-9. 122. Abraham WC, Robins A, Memory retention--the synaptic stability versus plasticity dilemma. Trends Neurosci. 2005 Feb;28(2):73-8. 123. Arshavsky YI, "The seven sins" of the Hebbian synapse: can the hypothesis of synaptic plasticity explain long-term memory consolidation? Prog Neurobiol. 2006 Oct;80(3):99-113. 124. Morrison JH, Hof PR, Life and death of neurons in the aging brain. Science. 1997 Oct 17;278(5337):412-9. 125. Merlo D, Di Stasi AM, Bonini P, Mollinari C, Cardinale A, Cozzolino F, Wisden W, Garaci E, DNA repair in post-mitotic neurons: a gene-trapping strategy. Cell Death Differ. 2005 Mar;12(3):307-9. 126. Nouspikel T, Hanawalt PC, Terminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression. Mol Cell Biol. 2000 Mar;20(5):1562-70. 127. Bielas JH, Non-transcribed strand repair revealed in quiescent cells. Mutagenesis. 2006 Jan;21(1):49-53.